Regensburg 2019 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 48: Biopolymers, Biomaterials and Bioinspired Functional Materials (joint session CPP/BP)
CPP 48.3: Vortrag
Mittwoch, 3. April 2019, 16:30–16:45, H13
Fast and on demand mussle-inspired adhesives by enzymatic polymerization of decapetides — •Maximilian Seuss1, Justus Horsch2, Patrick Wilke2, Matthias Pretzler3, Inga Melnyk1, Dario Remmler2, Annette Rompel3, Hans G. Börner2, and Andreas Fery1 — 1Leibniz-Institut für Polymerforschung Dresden e.V. — 2Humboldt-Universität Berlin — 3Universität Wien
A novel strategy to generate adhesive protein analogues by enzyme-induced polymerization of peptides is presented. Inspired by the repetitive nature of certain peptide sequences in mussel-foot protein mfp-1 we designed a polymerization reaction using these sequences as macromonomers. Peptide polymerization relies on tyrosinase oxidation of tyrosine residues to Dopaquinone, which rapidly forms cysteinyldopa with free thiols from cysteine residues. This forms a covalent bond between macromonomers and generates adhesive polymers. The resulting artificial protein analogues show strong adsorption to different surfaces, even resisting hypersaline conditions. Adhesion energies up to 10.9 mJ/m2 are found in single adhesion events and average values are superior to those reported for mussel foot proteins that constitute the gluing interfaces.