Regensburg 2019 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 64: Active Matter III (joint session BP/CPP/DY)
CPP 64.9: Vortrag
Freitag, 5. April 2019, 11:30–11:45, H11
Nanoscale chemotaxis of enzymes and small molecules — •Jaime Agudo-Canalejo1,2, Tunrayo Adeleke-Larodo1, Pierre Illien3, and Ramin Golestanian4,1 — 1University of Oxford, Oxford, UK — 2Penn State University, State College, USA — 3ESPCI Paris, Paris, France — 4Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany
We present a microscopic theory for the observed chemotaxis of enzymes and other small molecules. [1,2] We find that two distinct mechanisms contribute to enzyme chemotaxis: a diffusiophoretic mechanism due to non-specific interactions, and a new type of mechanism due to binding-induced changes in the diffusion coefficient of the enzyme. For a typical enzyme, the two mechanisms compete against each other, one dominating at high substrate concentration, the other at low concentration. The competition between the two mechanisms may be used to engineer nanovehicles that move towards or away from regions with a specific substrate concentration. Finally, we include the effects of anisotropy and flexibility of the enzyme, [3] and show that enzymes can be aligned by gradients, and shape fluctuations lead to corrections in the diffusion and chemotactic mobility of enzymes. [1] Agudo-Canalejo, J., Adeleke-Larodo, T., Illien, P., & Golestanian, R. (2018) Acc. Chem. Res. 51, 2365 [2] Agudo-Canalejo, J., Illien, P., & Golestanian, R. (2018) Nano Lett. 18, 2711 [3] Adeleke-Larodo, Agudo-Canalejo, J., & Golestanian, R. (2018) arXiv:1811.09631