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DY: Fachverband Dynamik und Statistische Physik
DY 23: Stochastic Thermodynamics
DY 23.2: Vortrag
Dienstag, 2. April 2019, 14:15–14:30, H20
Phase transition in thermodynamically consistent biochemical oscillators — •Basile Nguyen1, Udo Seifert1, and Andre C. Barato2 — 1II. Institut für Theoretische Physik, Universität Stuttgart, Stuttgart, Germany — 2Department of Physics, University of Houston
Biochemical oscillations are ubiquitous in living organisms. In an autonomous system, not influenced by an external signal, they can only occur out of equilibrium. We show that they emerge through a generic nonequilibrium phase transition, with a characteristic qualitative behavior at criticality. The control parameter is the thermodynamic force which must be above a certain threshold for the onset of biochemical oscillations. This critical behavior is characterized by the thermodynamic flux associated with the thermodynamic force, its diffusion coefficient, and the stationary distribution of the oscillating chemical species. We discuss metrics for the precision of biochemical oscillations by comparing two observables, the Fano factor associated with the thermodynamic flux and the number of coherent oscillations. Since the Fano factor can be small even when there are no biochemical oscillations, we argue that the number of coherent oscillations is more appropriate to quantify the precision of biochemical oscillations. Our results are obtained with three thermodynamically consistent versions of known models: the Brusselator, the activator-inhibitor model, and a model for KaiC oscillations.
[1] B. Nguyen, U. Seifert and A. C. Barato, J. Chem. Phys. 149, 045101 (2018)