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DY: Fachverband Dynamik und Statistische Physik

DY 26: Active matter I (joint session BP/CPP/DY)

DY 26.3: Vortrag

Mittwoch, 3. April 2019, 10:00–10:15, H4

Active Matter Invasion into Capillaries — •Felix Kempf¹, Romain Mueller², Erwin Frey¹, Juila Yeomans², and Amin Doostmohammadi² — ¹Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität München - Theresienstr. 37, D-80333 München, Germany — ²The Rudolf Peierls Centre for Theoretical Physics - Clarendon Laboratory, Parks Road, Oxford, OX1 3PU, UK

Biological active materials such as bacterial biofilms and eukaryotic cells thrive in confined microspaces. Here, we numerically show that combining growth dynamics with their intrinsic activity active material can use confinement as a mechanical guidance to achieve distinct modes of collective invasion. We assess the dynamics of the growing interface and classify these collective modes of invasion based on the activity of the active substance. While at small and moderate activities the active material grows as a coherent unit, we find blobs of active materials collectively detaching from the cohort above an activity threshold in a process reminiscent of the intravasation in cancer cells. We further characterise the mechanical mechanisms of transition between different modes of invasion.