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DY: Fachverband Dynamik und Statistische Physik

DY 48: Theory of Stochastic Processes with Applications in Biology (joint session SOE/BP/DY/AKjDPG)

DY 48.7: Topical Talk

Donnerstag, 4. April 2019, 18:00–18:30, H17

Reconstructing the topographic landscape of epithelial-mesenchymal plasticity — •Francesc Font-Clos, Stefano Zapperi, and Caterina A. M. La Porta — Center for Complexity and Biosystems, University of Milan, Italy

We construct a topographic map underlying epithelial-mesenchymal plasticity by combining numerical simulations, statistical physics methods and analysis of bulk and single-cell gene expression data. The map reveals a multitude of metastable hybrid phenotypic states, separating stable epithelial and mesenchymal states, and is reminiscent of the free energy measured in glassy materials and disordered solids.

Topography of epithelial-mesenchymal plasticity, Francesc Font-Clos, Stefano Zapperi, Caterina A. M. La Porta, Proceedings of the National Academy of Sciences Jun 2018, 115 (23) 5902-5907; DOI: 10.1073/pnas.1722609115