Regensburg 2019 – scientific programme
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MM: Fachverband Metall- und Materialphysik
MM 17: Nanomaterials
MM 17.5: Talk
Tuesday, April 2, 2019, 11:15–11:30, H46
Sorbitol capping of gadolinium oxide nanoparticles for contrast enhancement in magnetic resonance imaging — •Natalia Abrikosova1,2, Caroline Brommesson2, Peter Eriksson2, Zhangjun Hu2, and Kajsa Uvdal2 — 1Materials Modeling and Development Laboratory, National University of Science and Technology "MISIS", 119049 Moscow, Russia — 2Department of Physics, Chemistry, and Biology (IFM), Linköping University, SE-58183 Linköping, Sweden,
Diagnostic with magnetic resonance imaging (MRI) is the method of choice to detect diseases accompanied by an inflammation within the body. MRI contrast agents based on magnetic nanoparticles represent an efficient tool to improve image quality by enhancing the contrast between normal and diseased tissue, thereby increasing the utility of MRI. In this work, we report an investigation of the effect of sorbitol on the performance of Gd-oxide nanoparticles (GdNPs) as MRI contrast agents. Two sets of experiments were performed, where GdNPs were either capped to or immersed in sorbitol. The longitudinal relaxation rates for hematopoietic cell samples, were measured. The results show that the presence of sorbitol as capping layer on GdNPs clearly improves the nanoparticle performance. Moreover, measurements on human neutrophil granulocytes and the production of reactive oxygen species (ROS), evidently demonstrate improved biocompatibility of the GdNPs capped with sorbitol. We hereby conclude that the strategy to cap nanoparticles with sorbitol is a promising pathway in search for the next generation of MRI contrast agents.