Regensburg 2019 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
O: Fachverband Oberflächenphysik
O 69: Poster Wednesday: Organic Molecules on Inorganic Surfaces
O 69.11: Poster
Mittwoch, 3. April 2019, 17:45–20:00, Poster B2
Superhydrophilic/hydrophobic double-sided polycaprolactone-based scaffolds produced via DC plasma treatment — •Ksenia Stankevich1, Valeriya Kudryavtseva1, Yuri Zhukov2, Alexandra Pershina3, Victor Filimonov1, Evgeny Bolbasov1, and Sergei Tverdokhlebov1 — 1National Research Tomsk Polytechnic University, Tomsk, Russian Federation — 2Saint-Petersburg State University, Saint-Petersburg, Russian Federation — 3Siberian State Medical University, Tomsk, Russian Federation
Polymer biodegradable scaffolds treated with plasma possess the essential properties of biocompatible materials. However, hydrophobic recovery occurring after the plasma treatment limits the application of the method. Here, we create thin porous polycaprolactone- (PCL-) based scaffolds with a thin Ti coating by direct-current plasma treatment. The plasma activated surface allows for the subsequent linker-free immobilisation of hyaluronic acid (HA) that helps to retain improved wettability. As HA is attached only to the plasma treated area of the material, a scaffold with a hydrophobic side and a superhydrophilic side can be created. Appropriate modification did not affect the morphology or mechanical properties of the scaffold, while improving scaffold wettability. The immobilised HA not only conferred high biocompatibility, but also stabilised the superhydrophilic surface against hydrophobic recovery. Cell proliferation assay demonstrated better cell adhesion to hydrophilic side modified with HA rather than hydrophobic. The proposed approach can potentially realise biomaterials with gradual wettability from biodegradable polymers.