Regensburg 2019 – scientific programme

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O: Fachverband Oberflächenphysik

O 77: Organic Molecules on Inorganic Substrates V: Solid-Liquid Interfaces, Self-Organization, Ordering

O 77.1: Talk

Thursday, April 4, 2019, 10:30–10:45, H9

Self-assembly of phospholipids on Au(111) as a model system for the cytoplasmic membrane — •Iris Dorner¹, Ulrike Diebold¹, Gerhard J Schütz¹, and Stijn F L Mertens^1,2 — ¹TU Vienna, Institute of Applied Physics, Wiedner Hauptstr. 8-10/134, 1040 Vienna, Austria — ²Lancaster University, Department of Chemistry, LA1 4YB, Lancaster, United Kingdom

Lateral organization of lipids and proteins plays a crucial role in biological processes such as cell signalling. In order to understand the interactions governing the organization of amphiphilic molecules, a model system must provide access to nanoscale information at the interface between a 2D-confined phase and liquid water. We present such a model system in the self-assembled monolayer and bilayer of phospholipids on Au(111). We study the stages of adsorption and the dynamics of our model system with complementary imaging techniques, electrochemical scanning tunnelling microscopy, atomic force microscopy and single-molecule fluorescence microscopy. These shed light on the initial adsorption mechanism via the monolayer, bilayer formation, as well as the much discussed formation of ordered lipid domains such as rafts.