Regensburg 2019 – wissenschaftliches Programm
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O: Fachverband Oberflächenphysik
O 77: Organic Molecules on Inorganic Substrates V: Solid-Liquid Interfaces, Self-Organization, Ordering
O 77.3: Vortrag
Donnerstag, 4. April 2019, 11:00–11:15, H9
Conformation control of peptides on surfaces via metal coordination — •Sabine Abb1, Elise Duquesne2, Ludger Harnau1, Stephan Rauschenbach1,3, and Klaus Kern1,4 — 1Max Planck Institute for solid state research, Stuttgart, Germany — 2CNRS Paris, France — 3University of Oxford, UK — 4Ecole Polytechnique Fédérale de Lausanne, Switzerland
The conformation of peptides is defined by its sequence of amino acids and generally depends on the environmental conditions such as pH, salt concentration or temperature. Additionally, the coordination to metal centers can change the conformation, inducing also a change in the functionality of the peptide. Nearly half of all peptides/proteins are associated with metal coordination.
In this work, the metal-coordination complex is deposited by ES-IBD and investigated by STM. Here, we present the tailored conformation control of angiotensin-II (8 amino acids) on Au(111) by coordination to different metal centers. This is the first step towards rational design of surface supported peptide coordination complexes that can be relevant for different applications such as biomimetic catalysis.