Regensburg 2019 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: X-ray Imaging
ST 1.7: Vortrag
Montag, 1. April 2019, 16:45–17:00, H48
3D X-ray phase-contrast Histology — •Josef Scholz1,2, Lorenz Birnbacher1,2, Christian Petrich1,2, Franz Pfeiffer1,2, and Julia Herzen1,2 — 1Chair of Biomedical Physics, Department of Physics, TU Munich, Germany — 2Munich School of BioEngineering, TU Munich, Germany
The study of diseased tissue in anatomical pathology usually includes laborious pre-preparation processes, in particular staining and sectioning of the samples taken, before examination using light microscopy. Here, the sectioning process by itself causes a distortion of the individual slices and the subsequent arrangement of the 2D data results in anisotropic voxel sizes of the reconstructed 3D volume. Due to the comparably high sensitivity of grating based X-ray setups in terms of soft tissue variations, grating-based X-ray phase-contrast computed tomography (gbXPC-CT) constitutes a promising complementary method in histopathology, allowing for preliminary examination and localisation of diseased areas before sectioning non-destructively. Therefore, a resolution below 10 microns over a scan volume sufficient to the specimen size while not exceeding reasonable scan times has to be achieved, which remains a challenging problem using conventional lab sources. The presentation will show first results using a high-sensitivity gbXPC-CT setup.