Regensburg 2019 – wissenschaftliches Programm

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SYDN: Symposium Physics of Self-Organization in DNA Nanostructures

SYDN 1: Physics of Self-Organization in DNA Nanostructures

SYDN 1.5: Hauptvortrag

Donnerstag, 4. April 2019, 11:45–12:15, H1

Structural stability of DNA origami nanostructures under application-specific conditions — •Adrian Keller — Nanobiomaterials group, Technical and Macromolecular Chemistry, Paderborn University, Warburger Str. 100, 33098 Paderborn, Germany

With the introduction of the DNA origami technique, it became possible to synthesize almost arbitrarily shaped molecular nanostructures at nearly stoichiometric yields. The technique furthermore provides absolute addressability in the sub-nm range, rendering DNA origami nanostructures highly attractive substrates for the controlled arrangement of functional entities such as proteins, dyes, nanoparticles, DNA topologies, and drugs. Consequently, DNA origami nanostructures have found applications in numerous areas of fundamental and applied research, ranging from drug delivery to structural biology to inorganic materials synthesis. Since many of those applications rely on structurally intact, well-defined DNA origami shapes, the issue of DNA origami stability under numerous application-relevant environmental conditions has received increasing interest in the past few years. This talk will summarize our recent and ongoing activities aimed at identifying factors and parameters that determine DNA origami stability, denaturation, and degradation under conditions relevant for applications in biophysics and biomedicine.