Bonn 2020 – scientific programme

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ST: Fachverband Strahlen- und Medizinphysik

ST 1: Radiation monitoring and dosimetry I

ST 1.4: Talk

Tuesday, March 31, 2020, 11:45–12:00, H-HS II

Co-registration of ionoacoustics and ultrasound signals in a 3D printed realistic mouse phantom. — •Pratik Dash¹, Julie Lascaud¹, Hans-Peter Wieser¹, Ronaldo Kalunga¹, Benjamin Wollant¹, Walter Assmann¹, Jonathan Bortfeldt¹, Alessandro Stuart Savoia², and Katia Parodi¹ — ¹Ludwig-Maximilians-Universität München, Garching b. Munich, Germany — ²Department of Engineering, Roma Tre University, Rome, Italy

Proton therapy, owing to its pronounced maximum dose deposition (Bragg Peak-BP) at the end of its finite range in matter, allows for a highly conformal tumor irradiation. Ionoacoustic range verification uses thermoacoustic waves generated from irradiated regions to derive the BP positions, thereby enabling real-time treatment monitoring.

Superimposing ultrasound images with ionoacoustic signals requires both spatial and temporal co-registration between the two. The former is achieved by using the same transducer whereas the latter is achieved by using a synchronized trigger for data acquisition. Temporal co-registration was validated in simple water phantoms irradiated by a 20 MeV proton beam at the Maier-Leibnitz Laboratory in Munich. A dedicated procedure was then defined to correct for the time offset between the two signals (more specifically, their measurement triggers).

Finally, the effect of tissue heterogeneities in the medium was investigated by irradiating a 3D printed realistic mouse phantom. We demonstrated improved range verification accuracy and precise co-registration between the two modalities, facilitating a superposition of the pressure induced by 3D dose distribution and the mouse anatomy.