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ST: Fachverband Strahlen- und Medizinphysik
ST 6: Medical Imaging
ST 6.1: Vortrag
Donnerstag, 2. April 2020, 11:00–11:15, H-HS II
Contrast enhanced 3D X-ray histology: from preclinical to clinical applications — •Madleen Busse1, Simone Ferstl1, Melanie Kimm2, Mark Müller1, Enken Drecoll3, Toni Bürkner1, Sebastian Allner1, Lorenz Hehn1, Martin Dierolf1, Klaus Achterhold1, Julia Herzen1, Daniela Pfeiffer2, Ernst Rummeny2, Wilko Weichert3, and Franz Pfeiffer1,2 — 1Department of Physics and MSB, TU Munich, Garching, Germany. — 2Department of Diagnostic and Interventional Radiology, TU Munich, Munich, Germany. — 3Department of Pathology, TU Munich, Munich, Germany.
Histopathology is currently the diagnostic gold standard. It is, however, destructive providing only 2D information [1]. 3D X-ray histology overcomes these limitations by visualizing 3D tissue microstructure, which is essential for a holistic pathological characterization [2]. We recently developed a laboratory-based method enabling 3D virtual histology based on contrast enhanced nanoscopic X-ray CT [3]. Here, we present the application of this method to human biopsy samples. The CT slices reproduce crucial structures with a similar detail level as corresponding histological light microscopy images. Deeper insights into the 3D configuration of the tissue can be gained from our 3D data. In addition, compatibility with standard pathological stains highlights the feasibility of integrating our method into the pathological workflow. [1] S. K. Suvarna et al. (2013). Theory and Practice of Histological Techniques, Edn. 7th., Elsevier, Oxford. [2] M. Müller et al., Sci. Rep. 8 (1) (2018) 17855. [3] M. Busse et al., PNAS 115 (2018) 2293-2298.