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BP: Fachverband Biologische Physik

BP 12: Active Matter II (joint session BP/CPP/DY)

BP 12.7: Hauptvortrag

Dienstag, 17. März 2020, 11:30–12:00, HÜL 386

Physics of Growth: Another Form of Active Matter — •Jens Elgeti — Foschungszentrum Jülich, Germany Theoretical Soft Matter and Biophysics

Active matter is matter, driven out of equilibrium by its microscopic constituents. Growing mater is also active matter, but activity does not enter via the stress, but in material conservation. The material generates itself – think cells dividing or a tumor growing. Growth implies a change in volume. In physical terms, the conjugate force to volume is pressure. Thus, in order to grow, cells must exert mechanical pressure. In turn, pressure influences growth. This yields to interesting novel phenomena like infinite compressibility, self contracting materials and steady tread-milling states.

We use particle based simulations to study mechanical properties and effects in growing matter. These simulations have been helpful in understanding, interpreting and designing experiments. I will present an overview of the simulation technique, and several examples of how this model helped to gain insight in mechanical processes underlying tissue growth, ranging from growth of cancer spheroids under pressure [1], to in silico competition experiments [2-5] and tumor evolution [6].

[1] Montel et al., PRL 107, 188102 (2011)

[2] Podewitz et al., EPL 109, 58005 (2016)

[3] Basan et al., Phys. Biol. 8, 026014 (2011)

[4] Podewitz et al., New J. Physics 18, 083020 (2016)

[5] Ganai et al., New J. Phys. 21 063017 (2019)

[6] Büscher et al., arxiv:1910.03263 (2019)