Dresden 2020 – scientific programme
The DPG Spring Meeting in Dresden had to be cancelled! Read more ...
Parts | Days | Selection | Search | Updates | Downloads | Help
BP: Fachverband Biologische Physik
BP 17: Poster V
BP 17.10: Poster
Tuesday, March 17, 2020, 14:00–16:00, P2/1OG
First passage method to thermal fragmentation of amyloid fibrils — •Mohammadhosein Razbin1, Panayotis Benetatos2, and Ali Akbar Moosavi-Movahedi3 — 1Department of Energy Engineering and Physics, Amirkabir University of Technology, 14588 Tehran, Iran — 2Department of Physics, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea — 3Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
Using the mean first passage method, we calculated the fragmentation rate in a given position along an amyloid fibril. We consider the fibril as one dimensional Rouse chain. The thermal fluctuations define the first passage time (FPT) associated to the fragmentation of the chain. The fragmentation rate is the inverse of the average of the FPT. Our expression for the rate is a function of the number of monomers, the position of the fragmentation along the filament, the ratio of the bond energy to the thermal energy, and the Rouse relaxation time. Our model predicts the fragmentation rate of insulin fibrils under optimal growth conditions which is consistent with the experimental data.