Dresden 2020 – scientific programme

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BP: Fachverband Biologische Physik

BP 17: Poster V

BP 17.11: Poster

Tuesday, March 17, 2020, 14:00–16:00, P2/1OG

X-ray measurements of bovine red blood cells in continuous flow — •Jan-Philipp Burchert¹, Gerrit Brehm¹, Rita Graceffa¹, Manfred Burghammer², and Sarah Köster¹ — ¹Institut für Röntgenphysik, Georg-August-Universität Göttingen, Germany — ²European Synchrotron Radiation Facility, Grenoble, France

Due to their high penetration depth and resolution, X-rays are ideally suited to study structures and structural changes within biological samples. For this reason, X-ray-based techniques have been used by various authors to investigate adhesive cells on solid supports. However, these techniques cannot conveniently study suspended cells in flow. We developed an X-ray compatible microfluidic device that serves as a sample delivery system and measurement environment. In our experiments, this device is applied to measure fixed bovine red blood cells by small-angle X-ray scattering (SAXS). We find a good agreement between in-flow and static SAXS data. Thus, we demonstrate that suspended cells can be measured with SAXS in continuous flow.