Dresden 2020 – scientific programme

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BP: Fachverband Biologische Physik

BP 17: Poster V

BP 17.1: Poster

Tuesday, March 17, 2020, 14:00–16:00, P2/1OG

Surface Analysis of (Bioactive) Glasses and pH-dependent Protein Adsorption observed by X-ray Reflectometry — •Annemarie Prihoda, Michail Goldes, and Tobias Unruh — Institute of Crystallography and Structural Physics (ICSP), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Staudtstr. 3, 91058 Erlangen, Germany

Since 1977 bioactive glass has been used in medicine and dentistry as a bone implant or toothpaste ingredient. In contact with liquids a hydroxyapatite layer forms on the glass surface by releasing alkali metal ions from the glass surface. Osteoblasts adhere to this layer and thus form new bone structure (1). A basic understanding of the medical compatibility on a molecular level has, however, not been achieved yet.

We have tried to simulate the first steps of glass interaction after implantation by studying protein adsorption on glasses. We present X-Ray Reflectivity (XRR) data showing the adsorption of BSA on glasses (soda lime and borosilicate glass). We were able to identify protein layers whose thickness and roughness we determined on angstrom scale. Furthermore, we show the dependence of the degree of coverage on the pH-value of the protein solution. In addition, we are sensitive to aging effects of the glass surface, e.g. glass corrosion, which occurs when the glasses are immersed in liquids. For the first time we were able to characterize the surface of Bioglass 45S5 with XRR and compared the results to non-bioactive glasses.

(1) Baino F. et al. Journal of functional biomaterials 2018, 9 (1)