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BP: Fachverband Biologische Physik
BP 17: Poster V
BP 17.25: Poster
Dienstag, 17. März 2020, 14:00–16:00, P2/1OG
Analysis of red blood cells behaviour in a microfluidic device — •Amirreza Gholivand1,2, Knut Dahlhoff3, Timo Dickscheid4, and Minne Paul Lettinga1,2 — 1Laboratory of Soft Matter and Biophysics, KU Leuven, Leuven, Belgium — 2ICS-3 Soft Condensed Matter, Forschungszentrum Jülich, Jülich, Germany — 3ZEA-1 Engineering, Electronics and Analytics, Forschungszentrum Jülich, Jülich, Germany — 4INM-1 Neuroscience and Medicine, Forschungszentrum Jülich, Jülich, Germany
The blood flow dynamics through the micro-vascular system, which is the end of our vascular system, depend on many factors, such as the exact shape of the vessels, the aggregation and disaggregation and deformation of the red blood cells (RBCs). The effects of these parameters have been systematically studied in microfluidics, mainly using 2D channels with rectangular cross section, which are very different from the physiological vessels.
Here we present first data the flow of concentrated dispersions of (attractive) red blood cells in model 3-D microfluidic channels as well as physiologically relevant shaped channels. We used a novel technique, Selective Laser-induced Etching (SLE), to produce 3D structures in glass that allows the design of bifurcations into different planes with any desirable shape. To study the shape memory of the vessels the second generation of the bifurcation has been implemented with a parallel and perpendicular orientation relative to the first bifurcation,