Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 17: Poster V

BP 17.4: Poster

Dienstag, 17. März 2020, 14:00–16:00, P2/1OG

Interaction of Neuronal Cells with Electrode Materials — •Alice Abend, Chelsie Steele, and Mareike Zink — Universität Leipzig, Peter Debye Institut für Physik der weichen Materie, Leipzig, Deutschland

Deep brain stimulation of neuronal cells with neuroelectrodes is already employed for medical treatment of different diseases such as epilepsy and Parkinson's. Additionally, coupling of neuronal cells to multielectrode and lab-on-a-chip materials offers new perspectives in in-vitro assessments ranging from neuronal network formation to drug testing. However, many biomaterials lack the ability to promote adhesion of neurons important for biomaterial performance. Employing the human glioblastoma cell line U87-MG as well as the human neuroblastoma cell line SH-SY5Y, we investigate the neuronal cells' adhesion dynamics, bioactivity as well as network formation on custom-made electrode materials composed of gold, indium tin oxide, titanium nitride with and without nanocolumnar surface patterning.