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BP: Fachverband Biologische Physik
BP 18: Poster VI
BP 18.12: Poster
Dienstag, 17. März 2020, 14:00–16:00, P2/2OG
Parameter Optimization of a Cellular Potts Model using Multiple Micro-Pattern Cell Migration Experiments — •Sophia Anna Schaffer1, Andriy Goychuk2, Christoph Schreiber1, Erwin Frey2, and Joachim Rädler1 — 1Fakultät für Physik, Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, 80539 München — 2Arnold Sommerfeld Center, Ludwig-Maximilians-Universität, Theresienstraße 37, 80333 München
Modelling cell migration is important to simplify and understand the highly complex machinery of cells. Cellular Potts Models (CPMs) have been successfully used to reproduce cell migration patterns in two dimensions. They are capable to reproduce cell behavior with increasing levels of complexity and biological accuracy from single cells to collective migration. A particular challenge for computational simulations is to optimize model assumptions and parameters so that many experimental data sets are fitted simultaneously. Cells in confining geometries show restricted motion and various properties of cell behavior such as deformation, persistence, adhesion and polarization can be separately probed. Here, we still present a rational approach to use a set of geometries with complementary properties to determine parameter values successively in a systematic manner using one specific cell line. The general concept is to determine model parameters successively by using the emergent properties of the different geometry designs.