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BP: Fachverband Biologische Physik
BP 18: Poster VI
BP 18.6: Poster
Dienstag, 17. März 2020, 14:00–16:00, P2/2OG
Collective cell migration in 3D micro-tumours — •Tom Brandstätter1, David Brückner1, Yu Long Han2, Ming Guo2, and Chase Broedersz1 — 1Arnold-Sommerfeld-Center For Theoretical Physics and Center of NanoScience, LMU Munich, Germany — 2Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
The coordinated migration of cell collectives is key to many biological processes, including cancer progression. Here, we study the dynamical behaviour of in vitro micro-tumours. Initially, these micro-tumours are in a benign phase, exhibiting strongly correlated and highly persistent collective rotation of nearly all cells inside the spheroid. We investigate local interactions that can induce this collective mode of cell migration, using a physical minimal model for cell migration.
To constrain our models of interacting active particles, we analyse experimental data obtained from in vitro micro-tumours of various sizes. These experimental observations, including correlation functions and spatio-temporally resolved measures of the local persistence, place strong constraints on possible candidate models.
Furthermore, we find that these benign tumours eventually transition to a malignant state, which is characterized by an unconfined, non-definite shape with branches invading the surrounding tissue. Collective rotation is completely lost and the cancer cells show correlated but disordered motion. We aim to understand this drastic change in the collective behaviour in terms of the changes in single-cell behaviour and in cell-cell interactions.