Dresden 2020 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 19: Poster VII
BP 19.1: Poster
Dienstag, 17. März 2020, 14:00–16:00, P2/3OG
How to Pare a Pair: Topology Control and Pruning in Intertwined Complex Networks. — •Felix Kramer1,2 and Carl Modes1,2 — 1Center for Systems Biology Dresden (CSBD), Dresden, Germany — 2Max Planck Institut for Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany
Recent work on self-organized remodelling of vasculature in slime-mold, leaf venation systems or vessel systems in vertebrates has provided a plethora of potential adaptation mechanisms. All these have in common the underlying hypothesis of a flow driven machinery, meant to prune primary plexi in order to optimize the system's dissipation, flow uniformity or more, with different versions of constraints. Nevertheless, the long-term dynamics of adapting networks whose architecture and function is particularly dependent of their respective environment have not been properly understood. Therefore, interwoven capillary systems such as found in the liver, kidney and pancreas, present a novel challenge regarding the field of coupled distribution networks. We here present an advanced version of the discrete Hu-Cai model, coupling two spatial networks in 3D. We show that spatial coupling of two flow adapting networks can control the onset of topological complexity given the system is exposed to short-term flow fluctuations. Further, our approach results in an alternative form of Murray's law, which incorporates the local vessel interactions and flow fluctuations.