Dresden 2020 – scientific programme
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BP: Fachverband Biologische Physik
BP 19: Poster VII
BP 19.30: Poster
Tuesday, March 17, 2020, 14:00–16:00, P2/3OG
Theory of Active Transport by DNA-relaying — •Christian Hanauer1,2, Silke Bergeler1, Erwin Frey1, and Chase Broedersz1 — 1Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität, 80333 Munich, Germany — 2Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany
Robust and faithful segregation of chromosomes is essential for the replication of bacterial cells. In recent years, experiments have identified the biochemical and mechanical properties of the chromosome as key ingredients for active transport in bacterial cells. Intracellular cargos, such as chromosomal ori, are thought to use chromosome fluctuations to transport themselves along a guiding concentration gradient of DNA-binding ATPases. However, a theory for this DNA-relaying is still lacking. Here, we present a theoretical framework that allows us to calculate the relaying force on the cargo. We test our predictions by Brownian Dynamics simulations. Our analytical model provides insight into how the system parameters determine this active transport mechanism.