Dresden 2020 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 19: Poster VII
BP 19.7: Poster
Dienstag, 17. März 2020, 14:00–16:00, P2/3OG
Morphogenesis in Viscoelastic Tissues via Planar Deformations — •Abhijeet Krishna1,2, Jana Fuhrmann1, Joris Paijmans1,2,3, Suzanne Eaton1,2,3, Frank Jülicher1,2, Natalie Dye1, and Carl Modes1,2 — 1Max Planck Institute of Cell Biology and Genetics, Dresden, Germany — 2Center for Systems Biology Dresden, Dresden, Germany — 3Max Planck Institute of Physics of Complex Systems, Dresden, Germany
The mechanisms by which tissue surfaces develop to form complex 3D morphologies is an interesting question from the perspective of developmental biology. A model system for answering this question is the Drosophila wing imaginal disc which is a flat epithelial tissue that everts out of the plane to form a surface with non-zero Gaussian curvature. We are interested in understanding the mechanics of this eversion. It has been shown that before eversion, the cells in the wing disc elongate anisotropically and orient themselves in concentric circles around the central region of the tissue. Our hypothesis is that during eversion, cells lose their anisotropic characters which would lead to inhomogeneous and patterned planar deformations. Such inhomogeneous planar deformations can lead to change in the Gaussian curvature of the tissue. We build a spring-dashpot lattice model to simulate a viscoelastic and thick epithelial tissue. Using our model, we try to explain the robustness of the event of eversion. We also propose a mechanism by which eversion could be temporally controlled by the tissue.