Dresden 2020 – scientific programme

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BP: Fachverband Biologische Physik

BP 2: Focus: Phase Separation in Biological Systems I (joint session BP/CPP)

BP 2.7: Talk

Monday, March 16, 2020, 11:30–12:00, SCH A251

Stress granule formation via ATP depletion-triggered phase separation — Jean David Wurtz and •Chiu Fan Lee — Imperial College, London, U.K.

Stress granules (SG) are droplets of proteins and RNA that form in the cell cytoplasm during stress conditions. We consider minimal models of stress granule formation based on the mechanism of phase separation regulated by ATP-driven chemical reactions. Motivated by experimental observations, we identify a minimal model of SG formation triggered by ATP depletion. Our analysis indicates that ATP is continuously hydrolysed to deter SG formation under normal conditions, and we provide specific predictions that can be tested experimentally.

Reference: JD Wurtz and CF Lee (2018) New Journal of Physics 20, 045008.