Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 21: Cell Adhesion and Migration, Multicellular Systems I

BP 21.2: Vortrag

Mittwoch, 18. März 2020, 10:00–10:15, HÜL 386

Elongated Cells Fluidize Malignant Tissues — •Steffen Grosser, Jürgen Lippoldt, Linda Oswald, Frédéric Renner, and Josef A. Käs — Peter Debye Institute for Soft Matter Physics, Universität Leipzig

Tissue morphology changes during tumour progression. In 2D cell cultures, different tissue states, such as fluid, jammed and nematic, are linked to cell shapes. While it is not clear if these results hold true in three dimensions, they suggest to investigate cell shapes and tissue states of matter in 3D. To explain cell motility in tumors, we compare 3D cell spheroids composed of cells from a cancerous and a non-cancerous cell line. Through spheroid fusion experiments and live cell tracking, we show that the epithelial sample behaves solid-like and the malignant sample is fluidized by active cells moving through the tissue. Full 3D-segmentations of the samples show that the fluid-like tissue has elongated cell shapes. This links cell shapes to cell motility and bulk mechanical behaviour. We reveal two active states of matter in 3D tissues: an amorphous glass-like state with characteristics of 3D cell jamming, and a disordered fluid state.