Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 22: Single Molecule Biophysics (joint session BP/CPP)

BP 22.11: Vortrag

Mittwoch, 18. März 2020, 12:45–13:00, SCH A251

Probing single molecular surface interactions on electroactive surfaces — •Julia Appenroth, Laura Mears, Pierluigi Bilotto, Alexander Imre, and Markus Valtiner — TU Wien, Applied Physics, Vienna, AT

Adhesive interactions between hydrophobic, charged and electroactive moieties steer ubiquitous processes in aqueous media, including the self-organization of biologic matter and adhesive interfaces in general. Recent decades have seen tremendous progress in understanding these interactions for macroscopic adhesive interfaces. Yet, it is still a challenge to experimentally measure interactions at the single-molecule scale and thus to compare with theory, especially on electroactive surfaces. Here, we directly measure and quantify the sequence dependence and additivity of charge-mediated and electroactive interactions at the single-molecule scale. We combined dynamic single-molecule force spectroscopy with MD simulations and show how electroactive surfaces can be probed with single molecules using force probe techniques.