Dresden 2020 – scientific programme

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BP: Fachverband Biologische Physik

BP 22: Single Molecule Biophysics (joint session BP/CPP)

BP 22.5: Talk

Wednesday, March 18, 2020, 10:30–10:45, SCH A251

Towards the Label-free Plasmonic Detection of Single Untethered Proteins — •Martin D. Baaske, Peter S. Neu, Nasrin Asgari, and Michel Orrit — Huygens-Kamerlingh Onnes Laboratory, Leiden University, Postbus 9504, 2300 RA Leiden, The Netherlands

Label-free optical detection schemes so far rely on specific chemical interactions between receptor and target molecules in order to facilitate analyte recognition. Here we present our first step towards the label-free recognition of untethered nanoscale analytes. We show that via a polarization selective technique and careful optimization of a confocal microscope, single gold nanorods, which are commonly used as labels, can be transformed into high-speed nanoscale sensors. We demonstrate the performance of our system by detecting microemulsion nanodroplets which mimic 250 kDA proteins as they diffuse through the near field of a single gold nanorod on nanosecond timescales.