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BP: Fachverband Biologische Physik
BP 23: Focus: Physics of Stem Cells
BP 23.2: Vortrag
Mittwoch, 18. März 2020, 09:45–10:00, ZEU 250
How Tissue Microenvironment Impacts Pluripotent Cell Differentiation — •Allyson Quinn Ryan1,2, Chii Jou Chan1, François Graner2, and Takashi Hiiragi1 — 1Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany — 2Laboratoire Matière et Systèmes Complexes, Université Denis Diderot, Paris 7, Paris, France
The importance of stem cell population maintenance throughout both development and adulthood has been evident for several decades. Classically, how these populations are regulated is investigated through genetic and cell biological studies. However, work in the past 20 years has shown forces exerted by tissue microenvironments to be of equal importance as molecular and transcriptional profiles to cell potency and identity.1-3 In the context of the mammalian blastocyst, a multicellular system eventually comprised of three epithelial cell lineages, it has recently been shown that emergence of its asymmetrically localized fluid lumen influences the specification and positioning of the two multipotent interior cell lineages.4 The positioning and size of the blastocyst lumen are controlled through mechanisms favoring physical stability of the embryo in its entirety.5,6 Combined, these results point towards a framework of noncellular tissue entities influencing the specification and maturation of developmental tissues originating from progenitor populations of varying potency.
1. A. J. Engler et al., Cell 126, 677-689 (2005).
2. M. Théry et al. Nat., Cell Biol. 7, 947-953 (2005).
3. A.R. Cameron et al., Biomaterials 32, 5979-5993 (2011).
4. A.Q. Ryan et al. Dev., Cell 51, 1-14 (2019).
5. J.C. Chan et al., Nature 571, 112-116 (2019).
6. J.G. Dumortier et al. Science 365, 465-468 (2019).