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BP: Fachverband Biologische Physik

BP 27: Fluid Physics of Life (joint session DY/BP)

BP 27.2: Vortrag

Mittwoch, 18. März 2020, 15:30–15:45, ZEU 160

Wet-tip versus dry-tip regimes of osmotically driven bile flow in the liver — Oleksandr Ostrenko, Michael Kücken, and •Lutz Brusch — Center for Information Services and High Performance Computing (ZIH), Technische Universität Dresden, Germany

The secretion of osmolites into a lumen and thereby caused osmotic water inflow drive fluid flows like saliva, sweat and bile in organs without a mechanical pump, as opposed to the heart in blood circulation. The effects of elevated fluid pressure and the associated mechanical limitations of organ function remain largely unknown. We consider the pressure profile of the coupled osmolite-flow problem with combined velocity and pressure boundary conditions. Notably, the entire lateral boundary acts as a fluid source, the strength of which is determined by feedback from the emergent pressure solution itself. Hence, the pressure difference between the boundaries is not imposed but self-organises. Our theoretical results reveal fundamental parameter dependencies and a phase boundary separating the commonly considered ``wet-tip'' regime with steady flow out of the very tip of a channel from a ``dry-tip'' regime suffering stalled flow and a self-organised block of osmotic water inflow [1]. We validate model predictions against intra-vital video microscopy data from mouse liver [2] and propose a relation between the predicted phase boundary and the onset of zonated cholestasis, a pathological liver condition [3].

[1] Ostrenko et al. (2019) Scientific Reports 9, 4528. [2] Meyer et al. (2017) Cell Systems 4, 277. [3] Segovia-Miranda et al. (2019) Nature Medicine and bioRxiv 572073.