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BP: Fachverband Biologische Physik
BP 30: Cell Adhesion and Migration, Multicellular Systemadhesion and Migration, Multicellular Systems II
BP 30.6: Vortrag
Donnerstag, 19. März 2020, 11:30–11:45, HÜL 386
Migration of immune cells in an obstacle park — •Doriane Vesperini1, Zeinab Sadjadi3, Heiko Rieger3, and Franziska Lautenschläger1,2 — 1INM-Leibniz Institute for New Materials, 66123 Saarbrücken, Germany — 2Experimental Physics, Saarland University, 66123 Saarbrücken, Germany — 3Theoretical Physics, Saarland University, 66123 Saarbrücken, Germany
Several crucial processes in biological systems can be described as a search problem such as: finding food resources or pathogens. The presence of obstacles like non-targeted cells or extracellular matrix in biological environments induces a perturbation of the initial cell trajectory. For example, the presence of bystander cells has been shown to increase the velocity and the persistency of natural killer cells [1]. Besides obstacles density, their spatial disposition may also influence the search efficiency. It has been demonstrated that the density and geometry of pillar lattices affect migration strategies of cells [2].
We investigate how search efficiency is influenced by spatial arrangement of obstacles. A microfluidic device is designed to track HL-60 cells differentiated into neutrophils in confined 2D environments. Our device consists of pillar forests of different diameters distributed in triangular or square arrangements. We calculate the mean first passage time and diffusion properties of the searcher in different densities and geometries of pillars and investigate which key parameters influence the search efficiency.
[1] Zhou X., et al. Scientific Reports (2017)
[2] Gorelashvili M., et al. New Journal of Physics (2014)