Dresden 2020 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 32: Focus Session: Nonlinear Dynamics of the Heart I (joint session DY/BP)
BP 32.2: Vortrag
Donnerstag, 19. März 2020, 10:00–10:15, ZEU 118
Understanding the origin of line defects in heart tissue. — •Marcel Hörning1, Alessio Gizzi2, and Alessandro Loppini2 — 1University of Stuttgart, Stuttgat, Germany — 2University Campus Bio-Medico of Rome, Rome, Italy
Spatiotemporal patterns are observed in a wide range of excitable systems. They have important and diverse regulatory functions, such as regulation of cell migration of Dictyostelium cells, synchronization of electrophysiological dynamics in the cerebral neocortex, and maintenance of the contractility and cardiovascular blood circulation in mammalian hearts. In the heart, excitable waves can form complex oscillatory and chaotic patterns even at an abnormally higher frequency than normal heart beats, which increase the risk of fatal heart conditions by inhibiting normal blood circulation. Previous studies suggested that the occurrence of line defects in alternans play a critical role in the stabilizion of those undesirable patterns. However, this nonlinear phenomenon is still poorly understood. It remains to be elucidated, how nodal lines form, what their origin is, and how they stabilises. Here we show new insights in the stability of those by observing and analysing nodal line dynamics in spiral waves that exhibit stable alternans, and giving first clues on the origin of those.