Dresden 2020 – scientific programme
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BP: Fachverband Biologische Physik
BP 32: Focus Session: Nonlinear Dynamics of the Heart I (joint session DY/BP)
BP 32.3: Talk
Thursday, March 19, 2020, 10:15–10:30, ZEU 118
Optogenetic Control Spiral Wave Dynamics in Cardiac Tissue — •Sayedeh Hussaini1,2,4, Rupamanjari Majumder1,4, Valentin Krinski1,4, Ulrich Parlitz1,4, Stefan Luther1,2,3,4, and Claudia Richter1,4 — 1Max Planck Institute for Dynamics and Self-Organization, Goettingen, Germany — 2Institute for the Dynamics of Complex Systems, Goettingen, Germany — 3Institute of Pharmacology and Toxicology, Goettingen, Germany — 4German Center for Cardiovascular Research, Goettingen, Germany
Cardiac optogenetics may be used as a tool to elucidate the mechanisms underlying the dynamics and control of the spiral waves in the heart. Here we present a simulation study based on the ionically realistic Bondarenko model of mouse ventricular cardiomyocytes, coupled to a model for the light-activated protein Channelrhodopsin-2. We show that constant global sub-threshold illumination increases the resting membrane voltage, decreases the amplitude and the conduction velocity of the excitation wave. Periodic global illumination of the two-dimensional domain results in the transition of the spiral wave core of the trajectory from circular to epicycloidal and hypocycloidal. Using structured sub-threshold illumination, we induced spiral drift towards the boundary and subsequent termination. In the presence of an intensity gradient, the spiral wave drifts towards higher intensities.