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BP: Fachverband Biologische Physik
BP 33: Protein Structure and Dynamics
BP 33.11: Vortrag
Donnerstag, 19. März 2020, 12:45–13:00, ZEU 250
Control of (bio)nanoparticles with external fields — •Jannik Lübke1,2,3, Lena Worbs1,3, Armando Estillore1, Amit Kumar Samanta1, and Jochen Küpper1,2,3,4 — 1Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany — 2Center for Ultrafast Imaging, Universität Hamburg, Germany — 3Department of Physics, Universität Hamburg, Germany — 4Department of Chemistry, Universität Hamburg, Germany
Single-particle imaging (SPI) experiments rely on dense streams of isolated nanoparticles that are guided into the focus of free-electron lasers (FELs). Then typically diffraction data from arbitrary spatial orientations of the particles are collected, classified, combined into a three-dimensional (3D) diffraction volume and inverted to the underlying 3D structure of the sample [1].
To achieve atomic resolution, beams of many, ideally identical, particles need to be delivered into the FEL focus, which necessitates sample control methods to select nanoparticles. We develop and characterize various control techniques, such as particle beam focusing using fluid dynamics [2], temperature control [3], charge state state selectivity using electric fields [4], and further techniques. Here, we present novel approaches for the production of pure and high-density beams of a broad variety of biological nanoparticles, using external fields.
[1] M. M. Seibert et al., Nature 470, 78 (2011)
[2] N. Roth et al., J. Aerosol Sci. 124, 17 (2018)
[3] A. K. Samanta et al. arXiv:1910.12606 (2019)
[4] Y. P. Chang et al., Int. Rev. Phys. Chem. 34, 557 (2015)