Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 34: Nonlinear Dynamics of the Heart II (joint session DY/BP)

BP 34.4: Vortrag

Donnerstag, 19. März 2020, 15:00–15:15, ZEU 118

Feedback-based protocol for low-energy defibrillation — •Pavel Buran, Thomas Niedermayer und Markus Bär — Physikalisch-Technische Bundesanstalt (PTB), Berlin

Low-energy antifibrillation pacing (LEAP) is a method where electrical turbulence characteristic for atrial or ventricular fibrillation is suppressed by a series of low energy pulses [1]. Systematic simulation studies show that the choice of the right pacing period is crucial for successful LEAP [2]. However, the range of those successful pacing periods is a priori not known for a given tissue. Methods that efficiently determine the range of successful pacing periods are therefore of high interest. We have found, that termination probability of each individual pulse during LEAP depends exponentially on the total length of the interfaces between refractory and excitable parts of the tissue. Based on this finding, we present a feedback controlled protocol that ensures that pulses are applied in such a way to minimize the mentioned interface length in line with our earlier findings about the mechanism of LEAP. This protocol does not need any a priori information about the system and can thus also be used as an efficient method to determine the optimal pacing period.
[1] Luther et al., Nature 475, 235-239 (2011)
[2] Buran et al., Chaos 27, 113110 (2017)