Dresden 2020 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 34: Nonlinear Dynamics of the Heart II (joint session DY/BP)
BP 34.6: Vortrag
Donnerstag, 19. März 2020, 15:30–15:45, ZEU 118
Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media — Jan Lebert1,2,3 and •Jan Christoph1,2,3 — 1University Medical Center Göttingen, Germany — 2Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 3German Center for Cardiovascular Research, Partnersite Göttingen, Germany
Reconstructing electrical excitation wave dynamics within the heart muscle remains a major scientific challenge. Recently, it was shown using high-resolution 4D ultrasound that it is possible to identify mechanical filament-like phase singularities within the contracting, fibrillating heart wall, suggesting that the tissue mechanics reflect three-dimensional electrical scroll wave dynamics.
Here, we present a mechano-electrical data assimilation approach with which it is possible to reconstruct electrical excitation wave dynamics, including electrical vortex filaments, within the volume of deformable excitable media. By observing the spatio-temporal deformation patterns, which occur in response to the electrical excitation, the mechanical data is assimilated in a numerical replication of the observed elastic excitable system, and within this replication the data drives the intrinsic excitable dynamics, which then co-evolve and correspond to a reconstruction of the original dynamics. We provide a numerical proof-of-principle and demonstrate the performance of the approach by recovering even complicated three-dimensional scroll wave patterns.