Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 37: Systems Biology, Evolution and Neural Networks I

BP 37.2: Vortrag

Donnerstag, 19. März 2020, 15:30–15:45, ZEU 250

Ruggedness and accessibility in tradeoff induced landscapes — •Suman Das and Joachim Krug — University of Cologne, Cologne, Germany

Evolutionary fitness landscapes depend on environmental parameters. Contrary to the widespread attention given to fitness landscapes at fixed environments, the effect of environmental changes on gene-gene interactions has not been studied systematically. We study the case of environment dependent landscapes where the fitness effects of mutations exhibit adaptational tradeoffs, i.e mutations which are beneficial in one parameter regime become deleterious in another. We find that such landscapes have predictable properties that are largely independent of the precise details of individual parameter values in the system. In particular, we find that high ruggedness and high accessibility of fitness maxima coexist in these systems, making them distinct from the commonly studied random landscape models. We discuss the relevance of such landscapes in the context of antibiotic resistance.