Dresden 2020 – scientific programme

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BP: Fachverband Biologische Physik

BP 4: Membranes and Vesicles (joint session BP/CPP)

BP 4.9: Talk

Monday, March 16, 2020, 12:15–12:30, ZEU 250

The mechanism of vesicle-vesicle detachment under shear flow — •Mehdi Abbasi, Alexander Farutin, and Chaouqi Misbah — Univ Grenoble Alpes, CNRS, LIPhy, F-38000 Grenoble, France

Red blood cells (RBCs) suspended in plasma tend to aggregate and form rouleaux, during the aggregation they start by forming doublets of RBCs. In the physiological conditions the aggregation is reversible, the RBCs aggregate and disaggregate by the shear rate. In contrast, under some pathological conditions the aggregation becomes irreversible and once the aggregates formed they can not be dispersed again. Recently, D, Flormann et al analysed the doublet shape in the absence of applied flow in vitro and in silico. They observe that contact surface of the doublet starts by flat then sigmoid shape with the increase of adhesion energy. We performed two dimensional simulations to study the doublet dynamics under shear flow in different conditions and the effect of the doublet dynamics on the doublet suspension rheology, we also invesitigate the mechanism of vesicle-vesicle detachment.