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BP: Fachverband Biologische Physik
BP 6: Statistical Physics of Biological Systems I (joint session BP/DY)
BP 6.3: Vortrag
Montag, 16. März 2020, 15:30–15:45, SCH A251
Kauffman NK models interpolated between K=2 and K=3 — James E. Sullivan, Dmitry Nerukh, and •Jens Christian Claussen — Department of Mathematics, Aston University, Birmingham B4 7ET, U.K.
The NK model was introduced by Stuart Kauffman and coworkers [1] as a model for fitness landscapes with tunable ruggedness, to understand epistasis and pleiotropy in evolutionary biology. In the original formulation, fitness is defined as a sum of fitness functions for each locus, each depending on the locus itself and K other loci. Varying K from K=0 to K=N−1 leads to different ruggedness of the landscape. In previous work we introduced a generalization that allows to interpolate between integer values of K by allowing Ki to assume different values for each locus. We focus on the interpolation between the most widely studied cases of K=2 and K=3 and characterize the landscapes by study of their local minima. Here we transfer this approach to Random Boolean Networks and investigate attractor basins and limit cycles where the average K assumes integer and noninteger values. Relaxing the assumption of degree-homogeneity is an important step towards more realistic boolean network models, relevant to a broad range of applications in the dynamics of social systems and in systems biology.
[1] Kauffman, S.; Levin, S., Journal of Theoretical Biology. 128, 11 (1987); Kauffman, S.; Weinberger, E., Journal of Theoretical Biology. 141, 211 (1989).