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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 11: Focus: Phase Separation in Biological Systems I (joint session BP/CPP)

CPP 11.7: Vortrag

Montag, 16. März 2020, 11:30–12:00, SCH A251

Stress granule formation via ATP depletion-triggered phase separation — Jean David Wurtz and •Chiu Fan Lee — Imperial College, London, U.K.

Stress granules (SG) are droplets of proteins and RNA that form in the cell cytoplasm during stress conditions. We consider minimal models of stress granule formation based on the mechanism of phase separation regulated by ATP-driven chemical reactions. Motivated by experimental observations, we identify a minimal model of SG formation triggered by ATP depletion. Our analysis indicates that ATP is continuously hydrolysed to deter SG formation under normal conditions, and we provide specific predictions that can be tested experimentally.

Reference: JD Wurtz and CF Lee (2018) New Journal of Physics 20, 045008.