Dresden 2020 – scientific programme
The DPG Spring Meeting in Dresden had to be cancelled! Read more ...
Parts | Days | Selection | Search | Updates | Downloads | Help
CPP: Fachverband Chemische Physik und Polymerphysik
CPP 2: Focus: Soft Matter and Nanocomposites - New opportunities with advanced neutron sources I
CPP 2.10: Talk
Monday, March 16, 2020, 12:45–13:00, ZEU 222
Quantifying Nerve fibers in the Brain Section by Small Angle Scattering — •Santanu Maiti1,2, Henrich Frielinghaus3, Martin Dulle1, Markus Axer2, and Stephan Förster1 — 1Jülich Centre of Neutron Science (JCNS-1/ICS-1), Forschungszentrum Jülich GmbH (FZJ), Jülich, Germany — 2Institute of Neuroscience and Medicine (INM-1), FZJ, Jülich, Germany — 3Jülich Centre for Neutron Science at MLZ (JCNS-MLZ), FZJ, Garching, Germany
The structure and function of a brain is intricately linked to the structural connectome, i.e. the neurons and their connections [1]. The complete structural map of its nerve fibers and the exact quantification of their constituents is essential to understand the brain function, dys-function and neurodegenerative disease. Here, we map the whole brain section by small angle neutron/x-ray scattering (SANS/SAXS) to investigate the microstructural insights of the neurons [2-4]. We quantify the spatial distribution of the nerve cells and their degree of orientation from the anisotropic scattering signals. We determine also the orientation of myelinated axon and their orientational order over the section from the myelin peak. Finally, we compare them with 3D polarized light imaging (PLI) results to have a complete map of the connectome [5]. In future, the scanning neutron/X-ray imaging can serve as an alternating technique for neuroimaging. [1] C. S. von Bartheld et al, J. Comparative Neurology, 524, 3865 (2016). [2] H. Inouye et al., PLOS One. 9, e100592, (2014). [3] M. Georgiadis et al, NeuroImage, 204, 116214 (2020). [4] S. Foerster et al, Langmuir 31, 11678, (2015). [5] M. Axer et al Front. Neuroinform., 5, 34 (2011).