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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 31: Biomaterials and Biopolymers (joint session BP/CPP)
CPP 31.7: Vortrag
Montag, 16. März 2020, 17:00–17:15, ZEU 250
Experimental setups to mimic the Peritoneal Dialysis in humans — •Bernd Eberle1,2, Christian Wagner1, and Thomas John1 — 1Experimentalphysik, Universität des Saarlandes, Saarbrücken, Germany — 2Fresenius Medical Care Deutschland GmbH, St. Wendel, Germany
Peritoneal dialysis (PD) uses the peritoneum as a semipermeable dialysis membrane to clear the patient's blood. Therefore, dialysate solution gets filled into the abdominal cavity through an implanted catheter. Due to the osmotic concentration gradient between the blood capillarys and the dialysate, excess water and uremic toxins are removed from the blood by diffusing through the pores in the peritoneum into the dialysate. In contrast to Hemodialysis, the artificial filter membrane is well characterized, properties of the peritoneum are divers and vary for each patient. Consequently, a better understanding of membrane parameters is a crucial step for optimization treatment conditions. At present, commercially available software tools are used to simulate the membrane characteristics of the peritoneum but are lacking the precision to predict the ultrafiltration behavior in vivo. Hence, we present experiments which mimic the diffusion, convection and ultrafiltration through the peritoneum with artificial membranes allowing a patient-tailored PD-therapy with higher efficiency. Various osmotic agents and membrane compositions were investigated, and characteristic membrane parameters were extracted from the measurements.