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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 39: Charged Soft Matter, Polyelectrolytes and Ionic Liquids
CPP 39.6: Vortrag
Dienstag, 17. März 2020, 10:45–11:00, ZEU 114
The effects of ethanol and salt on the phase behavior and interactions of aqueous protein solutions — Rajeevann Uthayakumar, •Florian Platten, and Stefan U. Egelhaaf — Condensed Matter Physics Laboratory, Heinrich Heine University, Düsseldorf, Germany
The addition of salts or organic solvents to aqueous protein solutions alters their optical and dielectric properties and the interactions between protein molecules in these mixtures change accordingly. Here, the effects of NaCl and ethanol on the phase behavior and interactions of protein solutions are studied in terms of the metastable liquid-liquid phase separation and second virial coefficient B2 of lysozyme solutions. The cloud-point temperatures are reduced and raised by the addition of ethanol and salt, respectively. The extended law of corresponding states allows to interpret these trends as changes of B2. Remarkably, the dependence of B2 on both salt and ethanol content is quantitatively modelled by the DLVO theory.