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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 47: Focus: Phase Separation in Biological Systems II (joint session BP/CPP)

CPP 47.5: Hauptvortrag

Dienstag, 17. März 2020, 10:30–11:00, ZEU 250

Could the cytoskeleton influence liquid-liquid phase separation? — •Eric Dufresne — ETH Zürich, Department of Materials

We have recently demonstrated using synthetic polymers that mechanical stresses can have a dramatic impact on the phenomena of liquid-liquid phase separation [1-3]. Shin et al [4] recently revealed a coupling of condensation to chromatin density, suggesting that similar effects may play a role in the condensation of liquid droplets in the nucleoplasm.

Here, I will describe our new experiments exploring the interaction of phase-separated domains to elements of the cytoskeleton.

[1] Style, R. W. et al, Phys. Rev. X, 8, 011028 (2018)

[2] Kim, J.-Y. et al, arXiv:1811.00841 (2019)

[3] Rosowski, K. A. et al, arXiv:1907.08465 (2019)

[4] Shin, Y. et al, Cell 175 1481 (2018)