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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 91: Computational Biophysics (joint session BP/CPP)

CPP 91.10: Vortrag

Donnerstag, 19. März 2020, 12:30–12:45, SCH A251

Quantifying membrane curvature sensing — •Kai Steffen Stroh¹ and Herre Jelger Risselada^1,2 — ¹Institute for Theoretical Physics, Göttingen, Germany — ²Leiden Institute of Chemistry, Leiden, The Netherlands

When considering the interplay of lipid membranes and proteins, membrane curvature is an important factor, as it can act as a control mechanism for protein function. Several proteins feature subunits that serve as membrane curvature sensors. This sensing ability together with the spatial information provided by membrane curvature allows for site specific binding, and thus regulation of, e.g., transport processes.

Naturally, the curvature-dependent binding free energy provides valuable quantitative information about a protein’s curvature sensing abilities. Therefore, we present a novel molecular dynamics simulations protocol to obtain such free energy profiles.