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DY: Fachverband Dynamik und Statistische Physik

DY 12: Statistical Physics of Biological Systems I (joint session BP/DY)

DY 12.7: Vortrag

Montag, 16. März 2020, 17:00–17:15, SCH A251

Coarse graining of biochemical systems described by discrete stochastic dynamics — •David Seiferth and Stefan Klumpp — Institute for the Dynamics of Complex Systems, University of Göttingen, Friedrich Hund Platz 1, 37077 Göttingen, Germany

Many biological systems can be described by finite Markov models. A general method for simplifying master equations will be presented by merging two adjacent states. The method preserves the steady-state probability distribution and all steady-state fluxes disregarding the one between the merged states. As the order of merging states is not important, different levels of coarse-grained models of the underlying microscopic dynamics can be obtained. Different criteria for the level of coarse graining or the resolution of the process will be proposed. The application of the method will be discussed for specific biochemical examples.