Dresden 2020 – scientific programme
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DY: Fachverband Dynamik und Statistische Physik
DY 43: Statistical Physics of Biological Systems II (joint session BP/DY)
DY 43.8: Talk
Wednesday, March 18, 2020, 17:15–17:30, ZEU 250
Effective spin glass theories for gene regulatory networks — •Fabrizio Olmeda1 and Steffen Rulands1,2 — 1Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2Center for Systems Biology Dresden, Dresden, Germany
The development and maintenance of complex organs relies on precisely regulated cell fate decisions. Understanding the molecular mechanisms underlying these decisions is one of the central questions in stem cell biology.
The primary layer of regulation is the expression of genes and their interaction in gene regulatory networks. Here, by rigorously mapping the stochastic dynamics of gene regulatory networks to bipartite spin glasses, we develop an effective theory for describing fluctuations in gene regulatory networks during cellular decision making.
Performing a replica calculation, we describe the phase diagram that emerges in terms of the parameters of the gene network and demonstrate the existence of a spin glass phase.
In addition to the highly efficient simulation of gene networks our work, for the first time, allows using single-cell sequencing experiments to link fluctuations in gene expression to mechanisms of cellular decision making.