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DY: Fachverband Dynamik und Statistische Physik

DY 47: Focus Session: Nonlinear Dynamics of the Heart I (joint session DY/BP)

DY 47.8: Vortrag

Donnerstag, 19. März 2020, 12:00–12:15, ZEU 118

Constitutive modeling for failing heart regeneration — Moritz Kalhöfer-Köchling^1,3, Wolfram Zimmermann^2,3, Eberhard Bodenschatz^1,3, and •Yong Wang^1,3 — ¹MPI for Dynamics and Self-Organization, 37077 Göttingen, Germany — ²University Medical Center Göttingen, 37075 Göttingen, Germany — ³German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen, Germany

Heart failure is a common, costly, and potentially fatal condition in which the heart cannot pump enough blood to meet the body's needs. It is mainly caused by myocardial infarction, and associated with changes both in structure and function of the heart. Employing nonlinear solid mechanics, constitutive modeling is adopted to study cardiac mechanics and guide new therapy such as tissue engineered heart repair. To simulate the infarcted tissue as well as implanted engineered heart muscle, a novel class of constitutive models is proposed by considering fiber dispersion. Compared with their predecessors, those models improve the numerical stability, compute faster and are easier to implement. We also investigate the mechanical properties of heart muscle experimentally. This work was supported by the Max Planck Society and the German Center for Cardiovascular Research.