Dresden 2020 – scientific programme

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DY: Fachverband Dynamik und Statistische Physik

DY 51: Focus Session: Nonlinear Dynamics of the Heart II (joint session DY/BP)

DY 51.2: Talk

Thursday, March 19, 2020, 14:30–14:45, ZEU 118

Multiscale modeling of dyadic structure-function relation in ventricular cardiac myocytes — •Filippo Cosi^1,4,5, Wolfgang Giese², Wilhelm Neubert², Stefan Luther^1,4,5, Nagaiah Chamakuri³, Ulrich Parlitz^1,4,5, and Martin Falcke^2,5 — ¹Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — ²Max Delbrück Center for Molecular Medicine in the Helmholtz association, Berlin, Germany — ³Institute of Applied Mathematics, University of Hohenheim, Stuttgart, Germany — ⁴Georg-August-Universität Göttingen, Institute for the Dynamics of Complex Systems, Göttingen, Germany — ⁵DZHK (German Center for Cardiovascular Research), Partnersites Göttingen and Berlin, Germany

Understanding how defects in the subcellular components of single cardiomyocytes affect the calcium cycling in single cells can help to pin down the origin of cardiovascular disease. A multiscale model is used, which combines the stochastic nature of subcellular components (as Ryanodine Receptors, RyR or L-type Calcium Channels, LCC), their spatial arrangement as well as spatio-temporal calcium and buffer gradients at the whole-cell level. Recent findings regarding the geometrical clustering of RyRs and LCCs inspired us to include the physiological description of it into our mathematical model. The included structure modifications showed a dramatic effect on the model’s outputs; in detail the arrangement of RyRs has a strong impact on cell functions. Our study aims to lay a quantitative fundament for the analysis of defect cardiomyocytes under physiologically conditions to deepen the understanding of how diseased heart tissue might be treated.