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DY: Fachverband Dynamik und Statistische Physik
DY 51: Focus Session: Nonlinear Dynamics of the Heart II (joint session DY/BP)
DY 51.2: Vortrag
Donnerstag, 19. März 2020, 14:30–14:45, ZEU 118
Multiscale modeling of dyadic structure-function relation in ventricular cardiac myocytes — •Filippo Cosi1,4,5, Wolfgang Giese2, Wilhelm Neubert2, Stefan Luther1,4,5, Nagaiah Chamakuri3, Ulrich Parlitz1,4,5, and Martin Falcke2,5 — 1Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 2Max Delbrück Center for Molecular Medicine in the Helmholtz association, Berlin, Germany — 3Institute of Applied Mathematics, University of Hohenheim, Stuttgart, Germany — 4Georg-August-Universität Göttingen, Institute for the Dynamics of Complex Systems, Göttingen, Germany — 5DZHK (German Center for Cardiovascular Research), Partnersites Göttingen and Berlin, Germany
Understanding how defects in the subcellular components of single cardiomyocytes affect the calcium cycling in single cells can help to pin down the origin of cardiovascular disease. A multiscale model is used, which combines the stochastic nature of subcellular components (as Ryanodine Receptors, RyR or L-type Calcium Channels, LCC), their spatial arrangement as well as spatio-temporal calcium and buffer gradients at the whole-cell level. Recent findings regarding the geometrical clustering of RyRs and LCCs inspired us to include the physiological description of it into our mathematical model. The included structure modifications showed a dramatic effect on the model’s outputs; in detail the arrangement of RyRs has a strong impact on cell functions. Our study aims to lay a quantitative fundament for the analysis of defect cardiomyocytes under physiologically conditions to deepen the understanding of how diseased heart tissue might be treated.